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5 One specific trial showed benefit in patients without diabetes, finding reduced cardiovascular events in obese or overweight patients who already had diagnosed cardiovascular disease
In the SURMOUNT 1 trial, tirzepatide at doses of 5 mg, 10 mg and 15 mg were evaluated against placebo, with pooled tirzepatide groups resulting in significant decreases in total cholesterol, LDL-C, VLDL-C, FFA, and triglycerides and an increase in HDL-C at week 72 of follow-up [35]
At the center of much of this work is one bacterium that has drawn growing attention over the past decade: Akkermansia muciniphila
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IimuraYKurokawaTNojimaMKanemotoYYazawaKTsuritaGet al
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